Monday Night Football originates from Buffalo when the host the at 8:15 p.m. ET. Running back (knee) is out for the Patriots, while Bills back LeSean McCoy is questionable after suffering a concu sion. New England is on an incredible roll, racking up four consecutive wins in which they're averaging nearly 40 points a game. Buffalo, in just its third home game of the season, is looking to bounce back from a disappointing lo s in Indianapolis, but is 3-4 against the Logan Morrison Jersey spread. The Patriots opened as 13-point favorites and are now laying 13.5. The Over-Under is 44.5 in the latest Bills vs. Patriots odds. Before you make any Bills vs. Patriots picks, check out what the SportsLine Projection Model has to say.The advanced computer model simulates every NFL game 10,000 times and those who have followed it have seen ma sive returns. SportsLine's proprietary computer model went 176-80 last season and beat over 95 percent of CBS Office Pool players in 2016 and '17. It also performed better than 98 percent of experts tracked by NFLPickWatch.com during that span. Additionally, it went 48-34 on A-rated picks against the spread last season, and C. J. Cron Jersey $100 bettors who followed it the past two seasons are up nearly $4,000. It went 10-4 straight up in a wild Week 7, including calling the Patriots' huge win over the , improving its record to a blistering 71-34 on the season. And when it comes to top-rated picks, it is now on a strong 62-43 run. Anybody who has been following those picks is way, way up. Now, the model has simulated the Patriots vs. Bills on "Monday Night Football" 10,000 times. We can tell you it says the over cashes in 52 percent of simulations, and it has also found plenty of value on one side of the spread. This Tony Oliva Jersey pick is available only at SportsLine. The model has factored in that as long as is under center, the Patriots will almost always be favored. Brady has to sed 16 touchdown pa ses against seven interceptions. He's also on track to throw for 4,300 yards this season.Lined up in the Kirby Puckett Jersey backfield near Brady will be running backs Kenjon Barner and . While Michel is sidelined with a knee injury, Barner, formerly with the Philadelphia Eagles, should get plenty of touches, but White is the bigger threat. He leads the Patriots in both receptions (45) and touchdowns (seven).The Patriots have won four straight and covered three times over that span.But just because the Patriots have been hot doesn't mean they'll cover a two-touchdown spread in a divisional road game. A strong ground game capable of Kent Hrbek Jersey keeping the high-flying New England offense off the field and taking pre sure off Bills quarterback will be key to a Buffalo cover. Buffalo's top two running backs are banged up, but both are expected to play. leads the squad with 244 rushing yards, but has yet to hit pay dirt. Backup topped 100 yards from scrimmage last week in the blowout lo s to the .Who wins Patriots vs. Bills? And which side of the spread has all the value? .